Clopidogrel- What are the indications, and popular brands?

Clopicard Clopidogrel 75 mg Tablets for Cardiovascular, Packaging Type: Strips, Rs 93 /strip | ID: 12939806030

Parameters	Description
Category of Drug	Clopidogrel is an Antithrombotic Drug. Read more: Which are the popular Medicines prescribed for Heart Disorders?
Structure
IUPAC Name	methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
Molecular details	Mol. weight- 321.8 g/mol Mol formula- C₁₆H₁₆ClNO₂S
Mechanism of Action	It is a prodrug and gets metabolized by carboxylesterase-1 to form the active form that irreversibly binds to the P2Y₁₂ Adenosine diphosphate receptors on the platelets. This in turn inhibits the binding of adenosine diphosphate to the receptors and thereby blocks the ADP-mediated activation of glycoprotein GP IIb/IIIa complex. All these ultimately prevent the aggregation of platelets.
Indications	Clopidogrel is used for 1. Prophylaxis in thromboembolic disorders including myocardial infarction 2. Peripheral arterial disease and stroke 3. Acute coronary syndrome
Well Known Pharmaceutical Brands	CERUVIN- SUN CLAVIX- INTAS CLOPILET- SUN CLOPITAB- LUPIN CLOPIVAS- CIPLA DEPLATT-TORRENT PLAGERINE- MICRO PLAVIX- SANOFI PREVA- INTAS
Available dosage forms	TABLETS
Dose	1. Stroke- Adult- 75 mg once daily.
Contraindications	1. Hypersensitivity 2. Active pathological bleeding 3. Coagulation disorders 4. lactation
Precautions	1. Patient with increased risk of bleeding from trauma 2. Surgery or other pathological conditions 3. Ulcers 4. Renal impairment 5. Hepatic impairment 6. History of bleeding or haemostatic disorder 7. Pregnancy
Adverse Effects	1. Bleeding 2. Neutropenia 3. Thrombocytopenia 4. Other bone marrow toxicity 5. Diarrhoea 6. Epigastric pain 7. Rashes 8. Paraesthesia 9. Vertigo
Pregnancy Category	B