Clopidogrel

Clopidogrel- What are the indications, and popular brands?

ParametersDescription
Category of DrugClopidogrel is an Antithrombotic Drug.
Read more: Which are the popular Medicines prescribed for Heart Disorders?
StructureClopidogrel.png
IUPAC Namemethyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate
Molecular detailsMol. weight- 321.8 g/mol
Mol formula- C16H16ClNO2S
Mechanism of Action It is a prodrug and gets metabolized by carboxylesterase-1 to form the active form that irreversibly binds to the P2Y12 Adenosine diphosphate receptors on the platelets. This in turn inhibits the binding of adenosine diphosphate to the receptors and thereby blocks the ADP-mediated activation of glycoprotein GP IIb/IIIa complex. All these ultimately prevent the aggregation of platelets.
IndicationsClopidogrel is used for
1. Prophylaxis in thromboembolic disorders including myocardial infarction
2. Peripheral arterial disease and stroke
3. Acute coronary
syndrome
Well Known
Pharmaceutical Brands
CERUVIN- SUN
CLAVIX- INTAS
CLOPILET- SUN
CLOPITAB- LUPIN
CLOPIVAS- CIPLA
DEPLATT-TORRENT
PLAGERINE- MICRO
PLAVIX- SANOFI
PREVA- INTAS
Available dosage forms TABLETS
Clopicard Clopidogrel 75 mg Tablets for Cardiovascular, Packaging Type:  Strips, Rs 93 /strip | ID: 12939806030
Dose1. Stroke- Adult- 75 mg once daily.
Contraindications1. Hypersensitivity
2. Active pathological bleeding
3. Coagulation disorders
4. lactation
Precautions 1. Patient with increased risk of bleeding from trauma
2. Surgery or other pathological
conditions
3. Ulcers
4. Renal impairment
5. Hepatic impairment
6. History of bleeding or
haemostatic disorder
7. Pregnancy
Adverse Effects 1. Bleeding
2. Neutropenia
3. Thrombocytopenia
4. Other bone marrow toxicity
5. Diarrhoea
6. Epigastric pain
7. Rashes
8. Paraesthesia
9. Vertigo
Pregnancy Category B

References:

  1. National formulary
  2. properties
  3. general description
  4. MOA
  5. dosage and indications

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