| Category of Drug | Anticonvulsants/Antiepileptics drug |
| Mechanism of Action | Clonazepam is a potent anticonvulsant. Its primary mode of action is to facilitate GABAergic transmission in the brain by a direct effect on benzodiazepine receptors. |
| Indications | Clonazepam is used for 1. Absence seizures 2. Myoclonic seizures 3. Akinetic seizures 4. Panic disorder 5. Subcortical Myoclonus 6. Adjuvant treatment of refractory epilepsy. |
| Structure |  |
| Well Known Pharmaceutical Brands | 1. LONAZEP- SUN 2. ZAPIZ- INTAS PHARMA 3. CLONOTRIL- TORRENT PHARMA 4. RIVOTRIL- ABBOTT 5. CLONAFIT- MANKIND |
| Available dosage forms | TABLETS |
| Dose | 1.5 mg orally per day divided into 3 doses |
| Contraindications | 1. Hypersensitivity to benzodiazepines 2. Acute pulmonary insufficiency 3. Acute narrow angle 4. Glaucoma. |
| Precautions | 1. Neonates 2. chronic pulmonary insufficiency 3. Hepatic and renal dysfunction 4. Porphyria, 5. Elderly 6. Pregnancy 7. Lactation 8. Interactions |
| Adverse Effects | 1. Sedation 2. Dullness 3. CNS depression 4. Ataxia, 5. Bronchial hypersecretion 6. Abnormal eye movement 7. Blood dyscrasias. |
| Pregnancy Category | D |
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