| Category of Drug | Anticonvulsants/Antiepileptics drug |
| Mechanism of Action | Clobazam is known as potentiation of GABAergic neurotransmission resulting from binding at a benzodiazepine site at the GABA(A) receptor |
| Indications | Clobazam is used for 1. Add-on for refractory partial, complex and generalized seizures, 2. Add-on in West syndrome, LGS, myoclonic epilepsy, absence seizures, to cover a short period of increased seizure susceptibility addition of new AED examinations overnight travel catamenial epilepsy, 3. Intermittent prophylaxis in febrile seizures. |
| Structure |  |
| Well Known Pharmaceutical Brands | 1. FRISIUM- SANOFI 2. CLOBA- INTAS PHARMA 3. LOBAZAM- SUN |
| Available dosage forms | TABLETS |
| Dose | 5 mg PO once daily initially. Maximum dose in adults- 40 mg/day PO |
| Contraindications | 1. Benzodiazepine hypersensitivity 2. Coadministration with other CNS depressants 3. Dialysis, renal failure, renal impairment 4. Hepatic disease |
| Precautions | 1. Pregnancy 2. Interactions |
| Adverse Effects | 1. Sedation 2. dizziness 3. hyperactivity 4. behavioural problem 5. irritability 6. drooling 7. weight gain, 8. sleep disturbance 9. blurring 10. diplopia. |
| Pregnancy Category | D |
References