Amphotericin B- Drug Detail Profile

Category of Drug Amphotericin B- is an Anti-Infectives
Mechanism of Action 
Indications Amphotericin B is used for
1. Life-threatening fungal infections
2. Mucormycosis
3. Sporotrichosis and candidiasis
4. Visceral and mucocutaneous leishmaniasis unresponsive to pentavalent antimony compounds
5. Severe meningitis
6. Perioral candidiasis
Well Known
Pharmaceutical Brands
Available dosage forms VIALS
Contraindications 1. Toxic effects must be weighed against
2. Regular kidney
3. Liver function tests and blood counts must be conducted
4. Lactation
5. Antineoplastic therapy
Precautions 1. Close medical supervision throughout
treatment and inial test dose required
2. Renal impairment
3. Hepatic and renal function tests
4. Blood counts and plasma electrolyte monitoring
5. Corticosteroids
Adverse Effects1. Fever
2. Headache
3. Anorexia
4. Weight loss
5. Nausea and vomiting
6. Malaise
7. Diarrhoea
8. Muscle and joint pain
9. Dyspepsia and epigastric pain
10. Renal function disturbances
11. Blood disorders
12. Cardiovascular toxicity
13. Liver function
Pregnancy Category B

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