| Category of Drug | Amphotericin B- is an Anti-Infectives |
| Mechanism of Action | |
| Indications | Amphotericin B is used for 1. Life-threatening fungal infections 2. Mucormycosis 3. Sporotrichosis and candidiasis 4. Visceral and mucocutaneous leishmaniasis unresponsive to pentavalent antimony compounds 5. Severe meningitis 6. Perioral candidiasis |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | VIALS |
| Dose | |
| Contraindications | 1. Toxic effects must be weighed against benefits. 2. Regular kidney 3. Liver function tests and blood counts must be conducted 4. Lactation 5. Antineoplastic therapy |
| Precautions | 1. Close medical supervision throughout treatment and inial test dose required 2. Renal impairment 3. Hepatic and renal function tests 4. Blood counts and plasma electrolyte monitoring 5. Corticosteroids |
| Adverse Effects | 1. Fever 2. Headache 3. Anorexia 4. Weight loss 5. Nausea and vomiting 6. Malaise 7. Diarrhoea 8. Muscle and joint pain 9. Dyspepsia and epigastric pain 10. Renal function disturbances 11. Blood disorders 12. Cardiovascular toxicity 13. Liver function |
| Pregnancy Category | B |
