| Category of Drug | Alteplase is an Antithrombotic Drug |
| Mechanism of Action | |
| Indications | Alteplase is used for 1. Acute myocardial infarction 2. Acute massive pulmonary embolism 3. Acute ischaemic stroke |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | INJECTION |
| Dose | |
| Contraindications | 1. Uncontrolled hypertension with possible cerebrovascular haemorrhage 2. Recent surgery or trauma 3. Susceptibility to internal bleeding 4. Uncontrolled hypertension 5. Esophageal varices 6. Heavy vaginal bleeding 7. Bleeding diathesis 8. active peptic ulceration |
| Precautions | 1. Monitor for bleeding and BP in acute stroke 2. Caution in recent surgery or invasive procedures 3. Diabetic hemorrhagic retinopathy 4. Severe hepatic and renal impairment 5. Pregnancy 6. lactation 7. Children 8. Elderly 9. Interactions |
| Adverse Effects | 1. Haemorrhage including intracranial 2. Gastrointestinal or genitourinary bleeding 3. Transient hypotension 4. Reperfusion 5. Dysrhythmias 6. Cerebral edema 7. Seizures 8. Allergic-type reactions 9. Nausea 10. Vomiting |
| Pregnancy Category | C |
