Alendronate- Indications, Dosage, Contraindications, ADRs

Category of DrugAlendronate is a drug in Osteoporosis
SynonymAlendronate sodium hydrate 
Sodium alendronate trihydrate
Alendronate sodium trihydrate 
Alendronic acid monosodium salt trihydrate 
Mechanism of ActionAlendronic acid binds to bone hydroxyapatite. It then Inhibits osteoclasts resulting in decreased bone resorption.
Chemical structure Thumb
Molecular details Weight: 325.1237
Chemical Formula-C4H18NNaO10P2
IUPAC Namesodium trihydrate hydrogen (4-amino-1-hydroxy-1-phosphonobutyl) phosphonate
Indications Alendronate is used for
1. Treatment and prevention of postmenopausal osteoporosis
2. Glucocorticoid-induced

3. Paget’s disease
Well Known
Pharmaceutical Brands
Denfos-Dr. Reddys
Available dosage forms Tablet-
Dose 5-10 mg daily or 35-70 mg weekly
Contraindications1. Esophageal dysmotility
2. Esophageal obstruction
3. Esophageal ulcer
4. Hypocalcaemia
5. Hypersensitivity
6. Lactation
7. Interactions
Precautions1. History of ulcers
2. Hypocalcaemia
3. Severe renal insufficiency should be taken on an empty stomach and remain upright for not less than 30 minutes
Adverse Effects1. Oesophagitis
2. Abdominal pain with cramps
3. Abdominal swelling
4. Constipation
5. Diarrhoea
6. Dysphagia
7. Headache
8. Myalgia
9. Nausea
10. Vomiting
11. Peptic ulcer
12. Flatulence
13. Retrosternal pain
14. Bodyache
Pregnancy Category C

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