| Parameters | Details |
|---|---|
| Category of Drug | Alendronate is a drug in Osteoporosis |
| Synonym | Alendronate sodium hydrate Sodium alendronate trihydrate Alendronate sodium trihydrate Alendronic acid monosodium salt trihydrate |
| Mechanism of Action | Alendronic acid binds to bone hydroxyapatite. It then Inhibits osteoclasts resulting in decreased bone resorption. |
| Chemical structure |  |
| Molecular details | Weight: 325.1237 Chemical Formula-C4H18NNaO10P2 |
| IUPAC Name | sodium trihydrate hydrogen (4-amino-1-hydroxy-1-phosphonobutyl) phosphonate |
| Indications | Alendronate is used for 1. Treatment and prevention of postmenopausal osteoporosis 2. Glucocorticoid-induced osteoporosis 3. Paget’s disease |
| Well Known Pharmaceutical Brands | Osteofos-Cipla Restofos-Sun Denfos-Dr. Reddys |
| Available dosage forms | Tablet- |
| Dose | 5-10 mg daily or 35-70 mg weekly |
| Contraindications | 1. Esophageal dysmotility 2. Esophageal obstruction 3. Esophageal ulcer 4. Hypocalcaemia 5. Hypersensitivity 6. Lactation 7. Interactions |
| Precautions | 1. History of ulcers 2. Hypocalcaemia 3. Severe renal insufficiency should be taken on an empty stomach and remain upright for not less than 30 minutes |
| Adverse Effects | 1. Oesophagitis 2. Abdominal pain with cramps 3. Abdominal swelling 4. Constipation 5. Diarrhoea 6. Dysphagia 7. Headache 8. Myalgia 9. Nausea 10. Vomiting 11. Peptic ulcer 12. Flatulence 13. Retrosternal pain 14. Bodyache |
| Pregnancy Category | C |
