Activated Charcoal

Activated Charcoal-Antidote- Indications, Dosage, Contraindications, ADRs

Category of Drug Activated Charcoal-Antidote is Antidotes and Substances Used in Poisoning.
Chemical structure Thumb
Mechanism of Action Binds to the pharmaceutical drugs or poisons (e.g., organophosphates) to decrease the systemic absorption of poisonous or toxic agents.
Indications Activated Charcoal-Antidote is used for
1. Treatment of acute poisoning.
Well Known
Pharmaceutical Brands
Following brands available in combination therapy-
Anzyme Tab – Intas 
Distenil – Sun
Gasnil – Cipla 
Intazyme Cap – Intas 
Available dosage forms 1. POWDER
P’codynamic properties Gastric decontamination agent in- poison or medication overdose
P’cokinetic properties1. Adsorbs toxic substances
2. inhibits GI absorption
prevents or limits systemic toxicity
DoseAdult- 50g, 0.5g/kg.
If required- every 4-6 h for up to 12-24 h.
Contraindications1. Poisoning by hydrocarbons with high potential for harm if aspirated
2. Poisoning by corrosive substances-may prevent
visualization of lesions caused by poison
Precautions 1. Drowsy or unconscious patients-risk of aspiration
2. Effective for poisoning with alcohols
3. Clofenotane
4. Cyanides
5. Malathion and metal salts including iron and lithium
Adverse Effects 1. Black stools
2. Vomiting
3. Constipation or
4. Pneumonia-due to aspiration
Pregnancy Category unknown (it hasn’t been assigned an FDA pregnancy category for safety)

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