| Parameters | Details |
|---|---|
| Category of Drug | Activated Charcoal-Antidote is Antidotes and Substances Used in Poisoning. |
| Chemical structure |  |
| Mechanism of Action | Binds to the pharmaceutical drugs or poisons (e.g., organophosphates) to decrease the systemic absorption of poisonous or toxic agents. |
| Indications | Activated Charcoal-Antidote is used for 1. Treatment of acute poisoning. |
| Well Known Pharmaceutical Brands | Following brands available in combination therapy- Anzyme Tab – Intas Distenil – Sun Gasnil – Cipla Intazyme Cap – Intas |
| Available dosage forms | 1. POWDER 2. TABLETS |
| P’codynamic properties | Gastric decontamination agent in- poison or medication overdose |
| P’cokinetic properties | 1. Adsorbs toxic substances 2. inhibits GI absorption prevents or limits systemic toxicity |
| Dose | Adult- 50g, 0.5g/kg. If required- every 4-6 h for up to 12-24 h. |
| Contraindications | 1. Poisoning by hydrocarbons with high potential for harm if aspirated 2. Poisoning by corrosive substances-may prevent visualization of lesions caused by poison |
| Precautions | 1. Drowsy or unconscious patients-risk of aspiration 2. Effective for poisoning with alcohols 3. Clofenotane 4. Cyanides 5. Malathion and metal salts including iron and lithium |
| Adverse Effects | 1. Black stools 2. Vomiting 3. Constipation or diarrhoea 4. Pneumonia-due to aspiration |
| Pregnancy Category | unknown (it hasn’t been assigned an FDA pregnancy category for safety) |
