Category of Drug Anticonvulsants/Antiepileptics drug Mechanism of Action Clobazam is known as potentiation of GABAergic neurotransmission resulting from binding at a benzodiazepine site at the GABA(A) receptor Indications Clobazam is used for 1. Add-on for refractory partial, complex andgeneralized seizures, 2. Add-on in West syndrome, LGS, myoclonic epilepsy, absence seizures, to cover a short period of […]
Category of Drug Anticonvulsants/Antiepileptics drug Mechanism of Action Clonazepam is a potent anticonvulsant. Its primary mode of action is to facilitate GABAergic transmission in the brain by a direct effect on benzodiazepine receptors. Indications Clonazepam is used for1. Absence seizures2. Myoclonic seizures3. Akinetic seizures4. Panic disorder5. Subcortical Myoclonus6. Adjuvant treatment of refractory epilepsy. Structure Well
Category of Drug Sodium Valproate is a Anticonvulsants/Antiepileptics Mechanism of Action Anticonvulsant effect(1) of Sodium Valproate has been attributed to the blockade of voltage-gated sodium channels and increased brain levels of gamma-aminobutyric acid (GABA). Indications Sodium Valproate is used for1. Generalized tonic-clonic seizures2. Partial seizures3. Atonic seizures4. Absence seizures5. Myoclonic seizures6. Acute mania7. Migraine Well KnownPharmaceutical Brands
Category of Drug Fosphenytoin is an Anticonvulsants/Antiepileptics drug Mechanism of Action Fosphenytoin blocks frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials Indications Generalized tonic-clonic status epilepticus. Well KnownPharmaceutical Brands 1. FOSPHEN- INTAS PHARMA2. FOSOLIN-ZYDUS CADILA3. NEOFOST- NEON LABS Available dosage forms INJECTION Dose 10-20 mg PE/kg IV/IM Contraindications Porphyria. Precautions
