| Category of Drug | Sulfadoxine + Pyrimethamine is an Anti-Infectives drug |
| Mechanism of Action | |
| Indications | Sulfadoxine + Pyrimethamine is used for 1. Treatment of malaria due to susceptible P. falciparum in areas of high chloroquine resistance and in patients who have not responded to chloroquine 2. additionally quinine may be given for 3 days |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | 1. TABLETS 2. SUSPENSION |
| Dose | |
| Contraindications | 1. Hypersensitivity to sulfonamides or pyrimethamine 2. Severe hepatic or renal impairment 3. Blood dyscrasias 4. Neonates 5. Megaloblastic anaemia and folate deficiency |
| Precautions | 1. Avoid in blood disorders-unless specialist supervision 2. Discontinue immediately if blood disorder occurs 3. Rash 4. Sore throat 5. Mouth ulcers 6. shortness of breath-withdraw treatment 7. G-6-PD deficiency 8. Predisposition to folate deficiency 9. Hepatic impairment 10. Interactions 11. Pregnancy 12. Lactations |
| Adverse Effects | 1. Rashes 2. Pruritus 3. Slight hair loss 4. Erythema multiforme 5. Toxic epidermal necrolysis 6. Gastrointestinal disturbances 7. Hepatitis 8. Leukopenia 9. Thrombocytopenia 10. Megaloblastic anaemia |
| Pregnancy Category | C |
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