Sulfadoxine + Pyrimethamine

Sulfadoxine + Pyrimethamine- Drug Detail Profile

Category of DrugSulfadoxine + Pyrimethamine is an Anti-Infectives drug
Mechanism of Action 
Indications Sulfadoxine + Pyrimethamine is used for
1. Treatment of malaria due to susceptible
P. falciparum in areas of high chloroquine
resistance and in patients who have not
responded to chloroquine
2. additionally quinine may be given for 3 days
Well Known
Pharmaceutical Brands
Available dosage forms 1. TABLETS
Contraindications1. Hypersensitivity to sulfonamides or
2. Severe hepatic or renal
3. Blood dyscrasias
4. Neonates
5. Megaloblastic anaemia and folate
Precautions 1. Avoid in blood disorders-unless specialist
2. Discontinue immediately if blood disorder occurs
3. Rash
4. Sore throat
5. Mouth ulcers
6. shortness of breath-withdraw treatment
7. G-6-PD deficiency
8. Predisposition to folate deficiency
9. Hepatic impairment
10. Interactions
11. Pregnancy
12. Lactations
Adverse Effects 1. Rashes
2. Pruritus
3. Slight hair loss
4. Erythema multiforme
5. Toxic epidermal necrolysis
6. Gastrointestinal disturbances
7. Hepatitis
8. Leukopenia
9. Thrombocytopenia
10. Megaloblastic anaemia
Pregnancy Category C

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  1. Pingback: Which are the Popular Medicines prescribed for Malaria? > PharmaCampus

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