Prochlorperazine- Indications, Dosage, Contraindications, ADRs

Prochlorperazine is an Antiemetic prescribed for nausea and vomiting. Antiemetics treat motion sickness, chemotherapy-induced nausea and vomiting, and the side effects of general anesthetics and opioid analgesics.

Few medicines act on the chemoreceptor trigger zone-CTZ (in the brain) by preventing the stimulation. The chemoreceptor trigger zone is a vomiting center. Some medications act as prokinetic agents by speeding up the rate at which the stomach empties.

Category of DrugProchlorperazine is antiemetics drug
Mechanism of ActionProchlorperazine mainly blocks D2 dopamine receptors in the brain. 
Structure 1Prochlorperazine.png
Molecular weight 1Molecular formula- C20H24ClN3S
molecular weight- 373.9 g/mol
IUPAC Name 12-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
IndicationsProchlorperazine is used for
1. Nausea and vomiting
Pharmacokinetic properties 1. The onset of action- 30 to 40 minutes.
2. The duration of action-3 to 4 hours
3. protein binding- not known
4. Metabolism- undergoes hepatic metabolism involving oxidation. The oxidation reaction is mediated by CYP2D6
5.  mainly excreted via the feces and bile
6. half-life- 8 hours
Well Known
Pharmaceutical Brands
Stemetil- Abbott
Emidoxyn- Shreya
Emikind- Mankind
Available dosage forms1. TABLETS
Prochlorperazine Buccal Tablets | Pharmacy2U
DoseAdult- Nausea, vomiting acute attack: initially 20 mg then 20 mg every 2 h. Prevention; 5 to
10 mg 2 to 3 times daily.
Contraindications 1. Comatose states
2. CNS depression and
3. Most antipsychotics are best avoided during pregnancy
4. Hypersensitivity
5. Prolactin dependant tumours
Precautions 1. Patients with hepatic impairment
2. Renal impairment
3. Cardiovascular disease
4. Parkinson’s disease
5. Epilepsy
6. Depression
7. Myasthenia gravis
8. Prostatic hypertrophy
9. Susceptibility to angle-closure glaucoma
Adverse Effects 1. Less sedating
2. Extrapyramidal symptoms
3. Particularly dystonias
4. Respiratory depression may occur in susceptible patients
5. Amenorrhoea
6. Blurred vision
7. Cholestatic jaundice
8. Neuroleptic malignant syndrome
9. Leucopenia
10. Agranulocytosis
Pregnancy Category C


National FOrmulary

Drug profile 2, 3, 4

1 thought on “Prochlorperazine- Indications, Dosage, Contraindications, ADRs”

  1. Pingback: Gastroenterology: Which are the popular Brands? - PharmaCampus

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top