Pralidoxime (2-PAM)

Pralidoxime (2-PAM)- Drug Detail Profile

Category of DrugPralidoxime (2-PAM) is an Antidotes and Substances Used in Poisoning
Mechanism of Action 
Indications Pralidoxime (2-PAM) is used for
1. Adjunct to atropine in the treatment
of organophosphate poisoning and
anticholinesterase overdosage used in
the treatment of myasthenia gravis (mg)
2. Respiratory depression or severe muscle
weakness due to carbamate poisoning
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications 1. Carbamate poisoning and organophosphates
without anticholinesterase activity
2. Hypersensitivity to the drug
Precautions 1. Impaired renal function
2. Large doses can cause neuromuscular blockade
3. Myasthenia gravis
4. Atropinizaon occur faster on concurrent use with atropine
5. Paediatrics
6. Allergies
7. Pregnancy
Adverse Effects 1. Nausea
2. Vomiting
3. Blurred vision
4. Impaired accommodation
5. Headache
6. Dizziness
7. Hyperventilation
8. Muscular weakness
9. Transient elevation in SGOT/SGPT levels
Pregnancy Category C

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top