Phenobarbitone- Drug Detail Profile

Category of Drug Phenobarbitone is a  Anticonvulsants/Antiepileptics drug
Mechanism of Action 
Indications Phenobarbitone is used for
1. Generalized tonic-clonic seizures
2. Partial seizures
3. Neonatal seizures
4. Febrile convulsions
5. Status epilepsy
6. Sedative
7. Hypnotic
8. Pre-anaesthetic.
Well Known
Pharmaceutical Brands
Available dosage forms1. TABLETS
Contraindications 1. Absence seizures
2. Latent porphyria.
Precautions1. Elderly
2. Debilitated
3. Children
4. Impaired Renal function
5. Respiratory Depression
6. Pregnancy
7. Lactation
8. Avoid sudden withdrawal
Adverse Effects 1. Sedation, mental depression, agitation,
hallucination, syncope;
2. Ataxia, nystagmus;
3. Allergic skin reactions including rarely, exfoliative dermatitis, toxic epidermal necrolysis, Steven’s-
Johnson syndrome
4. Paradoxical excitement
5. Restlessness and confusion in the elderly
6. Irritability and hyperactivity in children
Pregnancy Category D

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