| Category of Drug | Metronidazole is an Anti-Infective drug |
| Mechanism of Action | Metronidazole diffuses into the organism, inhibits protein synthesis (1)by interacting with DNA, and causing a loss of helical DNA structure and strand breakage. |
| Indications | Metronidazole is used for 1. Anaerobic bacterial infections 2. Tissue nematode infections 3. Trichomonal vaginitis 4. Amoebiasis and giardiasis 5. Helicobacter pylori eradication |
| Well Known Pharmaceutical Brands | METROGYL-UNIQUE PHARM FLAGYL- ABBOTT METRON- ALKEM METROHEX- DR REDDYS LABS  |
| Available dosage forms | 1. TABLETS 2. SUSPENSION 3. INJECTION |
| Dose | 500 mg four times a day for 7–10 days. |
| Contraindications | Chronic alcohol dependence; first trimester of pregnancy. |
| Precautions | 1. Disulfiram-like reaction with alcohol 2. Hepatic impairment and hepatic encephalopathy 3. lactation 4. Clinical and laboratory monitoring in courses lasting longer than 10 days 5. Interactions 6. Pregnancy |
| Adverse Effects | 1. Nausea 2. Vomiting, 3. Unpleasant metallic taste 4. Furred tongue and gastrointestinal disturbances 5. Headache 6. Drowsiness 7. Dizziness 8. Ataxia 9. Darkening of urine 10. Epileptiform seizures 11. leukopenia on prolonged or high dosage regimens; paresthesia |
| Pregnancy Category | B |
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