Imipenem + Cilastatin

Imipenem + Cilastatin- Drug Detail Profile

Category of DrugImipenem + Cilastatin  is an Anti-Infective drug
Mechanism of Action 
Indications Imipenem + Cilastatin is used for
Severe aerobic and anaerobic Gram-positive and Gram-negative infections in hospital-acquired infections
Well Known
Pharmaceutical Brands
Available dosage forms INJECTION
Contraindications 1. Hypersensitivity to beta-lactam antibiotics
2. Local anaesthetics of the amide-type and in
patients with severe shock or heart block.
Precautions 1. Renal impairment
2. CNS disorders
3. Pregnancy
4. Lactations
5. Interactions
Adverse Effects1.  Nausea
2. Vomiting
3. Diarrhoea
4. Antibiotic-associated colitis
5. Taste disturbances
6. Tooth or tongue discolouration
7. Hearing loss
8. Blood disorders
9. Positive Coombs’ test
10. Allergic reactions
11. A slight increase in liver enzymes and bilirubin
Pregnancy Category C

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