Hydralazine- Indications, Dosage, Contraindications, ADRs

Category of Drug Hydralazine is Antihypertensive Drugs
Mechanism of Action 
Indications Hydralazine is used for
1. In combination therapy in moderate to severe hypertension
2. Hypertensive crisis
3. Hypertension associated with pregnancy
Well Known
Pharmaceutical Brands
Available dosage forms1. TABLET
Contraindications 1. Idiopathic systemic lupus erythematosus
2. Severe tachycardia
3. High output heart failure
4. Myocardial insufficiency due to mechanical obstruction
5. Cor pulmonale
6. Dissecting aortic aneurysm
7. Porphyria
8. Angina
9. Mitral valvular heart disease
10. Rheumatic disease
Precautions 1. Hepatic impairment
2. Renal impairment
3. Coronary artery disease
4. Cerebrovascular disease
5. Check acetylator status before
increasing dose above 100 mg daily
6. Test for antinuclear factor and for proteinuria every 6 months
7. Coronary artery disease
8. Alcohol intake
9. Lactation
Adverse Effects 1. Tachycardia
2. Palpitations
3. Postural hypotension
4. Fluid retention
5. Gastrointestinal disturbances
6. Constipation
7. Dizziness
8. Flushing
9. Headache
10. Abnormal liver function
11. Systemic lupus erythematosus-like syndrome
Pregnancy Category C

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