Cyclosporine- Indications, Dosage, Contraindications, ADRs

Category of DrugCyclosporine is an Immunosuppressives Drug
Mechanism of Action 
Indications Cyclosporine is used for
1. Rejection in kidney, liver, heart or bone- marrow transplantation
2. Graft-versus-host disease
3. In severe recalcitrant atopic
Well Known
Pharmaceutical Brands
Available dosage forms1. CAPSULES
Contraindications 1. Patients affected by psoriasis
Precautions 1. Monitor kidney function
2. Monitor liver function
3. Monitor blood pressure
4. Monitor serum potassium
5. Renal impairment
6. Monitor serum magnesium
7. Hyperuricaemia
8. Measure blood lipids before
and during treatment
9. Avoid in porphyria
10. Vaccination ineffective
11. Monitor serum
12. Creatinine levels
Adverse Effects 1. Dose-related and reversible increases in serum creatinine and urea unrelated to tissue rejection
2. Burning sensation in hands and feet during inial therapy
3. Electrolyte disturbances
4. Hepatic dysfunction
5. Hyperuricaemia
6. Hypercholesterolaemia
7. Increased incidence of malignancies and lymphoproliferative disorders
8. Gastrointestinal disturbances
9. Gingival hyperplasia
10. Thrombocytopenia
Pregnancy Category C

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