| Category of Drug | Cyclosporine is an Immunosuppressives Drug |
| Mechanism of Action | |
| Indications | Cyclosporine is used for 1. Rejection in kidney, liver, heart or bone- marrow transplantation 2. Graft-versus-host disease 3. In severe recalcitrant atopic dermatitis |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | 1. CAPSULES 2. INFUSION 3. INJECTION |
| Dose | |
| Contraindications | 1. Patients affected by psoriasis |
| Precautions | 1. Monitor kidney function 2. Monitor liver function 3. Monitor blood pressure 4. Monitor serum potassium 5. Renal impairment 6. Monitor serum magnesium 7. Hyperuricaemia 8. Measure blood lipids before and during treatment 9. Avoid in porphyria 10. Vaccination ineffective 11. Monitor serum 12. Creatinine levels |
| Adverse Effects | 1. Dose-related and reversible increases in serum creatinine and urea unrelated to tissue rejection 2. Burning sensation in hands and feet during inial therapy 3. Electrolyte disturbances 4. Hepatic dysfunction 5. Hyperuricaemia 6. Hypercholesterolaemia 7. Increased incidence of malignancies and lymphoproliferative disorders 8. Gastrointestinal disturbances 9. Gingival hyperplasia 10. Thrombocytopenia |
| Pregnancy Category | C |
