| Parameters | Description |
|---|---|
| Category of Drug | Ceftriaxone is an Anti-Infective drug |
| Mechanism of Action | Ceftriaxone selectively and irreversibly inhibits bacterial cell wall synthesis by binding to transpeptidases, also called transamidases |
| Indications | Ceftriaxone is used for 1. Serious infections due to sensitive bacteria 2. Including septicemia 3. Pneumonia and meningitis 4. Surgical prophylaxis 5. Prophylaxis of meningococcal meningitis 6. Gonorrhea |
| Well Known Pharmaceutical Brands | MONOCEF-ARISTO PHARMA XONE-ALKEM FINECEF INJ-ABBOTT MONOCEF-ARISTO PHARMA TRAXOL-ALKEM MONOTAX-ZYDUS CADILA ODICEF-GALPHA LABS CEFBACT-CIPLA |
| Available dosage forms | INJECTION |
| Dose | 1-2 g/day IV in a single daily dose or divided into two doses for 4-7 days |
| Contraindications | 1. Cephalosporin hypersensitivity 2. Porphyria 3. Neonates with jaundice 4. Hypoalbuminaemia 5. Acidosis or impaired bilirubin binding |
| Precautions | 1. Penicillin sensitivity 2. Severe renal impairment 3. Hepatic impairment if accompanied by renal impairment 4. Premature neonates 5. May displace bilirubin from serum albumin 6. Renal failure 7. Dehydration or concomitant total parenteral nutrition-risk of ceftriaxone precipitation in the gallbladder 8. Lactation 9. Pregnancy 10. false-positive urinary glucose |
| Adverse Effects | 1. Diarrhoea 2. Nausea and vomiting 3. Abdominal discomfort 4. Headache 5. antibiotic-associated colitis 6. allergic reactions including rashes, pruritus, urticaria 7. Serum sickness-like reactions 8. Fever and arthralgia and anaphylaxis 9. Erythema multiforme 10. Toxic epidermal necrolysis reported 11. Hypersensitivity |
| Pregnancy Category | D |
References
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