What is Amoxycillin + Clavulanic acid, popular brands, and indications?

Category of Drug	Amoxycillin + Clavulanic acid is an Anti-Infective drug
Mechanism of Action	Amoxicillin binds to penicillin-binding proteins within the bacterial cell wall and inhibits bacterial cell wall synthesis. Clavulanic acid is a β-lactam, structurally related to penicillin, that may inactivate certain β-lactamase enzymes.
Indications	Amoxycillin + Clavulanic acid is used for 1. Treatment of infections caused by susceptible organisms 2. Sinusitis 3. Otitis media 4. Dental abscesses 5. Severe respiratory tract infections 6. Urinary tract infections 7. Skin and so tissue infections
Well Known Pharmaceutical Brands	AUGMENTIN- GSK CLAVAM- ALKEM FIGHTOX- ABBOTT ADVENT- CIPLA MEGA-CV- ARISTO PHARMA FLEMICLAV- FDC AUGPEN- EMCURE
Available dosage forms	1. TABLETS 2. CAPSULES 3. SUSPENSION 4. INJECTION
Dose	The usual adult dose is one 500-mg tablet of every 12 hours or one 250-mg tablet every 8 hours
Contraindications	1. Hypersensitivity to penicillins 2. Infectious mononucleosis 3. Jaundice
Precautions	1. Renal impairment 2. Hepatic dysfunction 3. Patients on anticoagulant therapy 4. Pregnancy 5. Lactations
Adverse Effects	1. GI upset 2. Mycosis 3. rash 4. nausea 5. vomiting, 6. anaphylaxis 7. cholestatic jaundice 8. blood dyscrasias 9. Toxic epidermal necrolysis 10. Convulsions 11. Exfoliative dermatitis
Pregnancy Category	C

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