Amiodarone- Indications, Dosage, Contraindications, ADRs

Category of Drug Amiodarone is Antiarrhythmic Drugs
Mechanism of Action 
Indications Amiodarone is used for
1. A severe rhythmic disorder where other therapies cannot be used including tachyarrhythmia associated with Wolff-Parkinson-White syndrome
2. Atrial flutter and fibrillation
3. All types of paroxysmal
Well Known
Pharmaceutical Brands
Available dosage forms 1. TABLETS
Contraindications 1. Sinus bradycardia
2. Sino-atrial heart block
3. Unless pacemaker fitted avoid in severe conduction disturbances or sinus node disease
4. Thyroid dysfunction
5. Iodine sensitivity
6. Goitre
7. Avoid intravenous use
in severe respiratory failure
8. Circulatory collapse
9. Severe arterial hypotension
10. avoid bolus injection in congestive heart failure
or cardiomyopathy
11. lactation
12. Pregnancy
Precautions 1. Liver-funcon and thyroid-function tests required before treatment and then every
6 months
2. Hypokalaemia
3. Chest x-ray required before treatment
4. Heart failure
5. Elderly
6. Severe bradycardia and
conduction disturbances in excessive dosage
7. Intravenous use may cause moderate and transient fall in blood pressure
8. ECG monitoring and resuscitation facilities
must be available during intravenous use
Adverse Effects 1. Nausea
2. Vomiting
3. Taste disturbances
4. Raised serum transaminases
5. Jaundice
6. Bradycardia
7. Pulmonary toxicity
8. Tremor
9. Sleep disorders
10. Hypothyroidism
11. Hyperthyroidism
12. Reversible corneal microdeposits
13. Phototoxicity
14. Persistent slate-grey
skin discolouration
15. Conduction disturbances
16. Peripheral neuropathy and
17. Chronic liver disease including
18. Bronchospasm
19. Vertigo
Pregnancy Category D

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