| Parameters | Details |
|---|---|
| Category of Drug | Cytosine Arabinoside (Cytarabine) is an antineoplastic anti-metabolite |
| Mechanism of Action | Cytarabine acts by interfering with DNA synthesis. Cytarabine is cytotoxic and acts through the inhibition of DNA polymerase. It exhibits cell phase specificity, blocking cells’ progression from the G1 phase to the S-phase. |
| Indications | Cytosine Arabinoside (Cytarabine) is used for 1. Acute lymphoblastic leukemia 2. Chronic myeloid leukemia 3. Meningeal leukemia 4. Erythroleukaemia 5. Non-Hodgkin’s lymphomas 6. lymphosarcoma |
 | |
| Molecular Details | Weight: 243.2166 Chemical Formula- C9H13N3O5 |
| Well Known Pharmaceutical Brands | CYTOSAR- PFIZER CYTARINE- FRESENIUS KABI BIOBIN- ZYDUS CADILA CYTANEON- NEON LABS |
| Available dosage forms | INJECTION |
| Dose | Intravenous injection- 100 mg/m2 body surface area every 12 h for seven days. (in Adults) |
| Contraindications | 1. Hypersensitivity 2. Pregnancy 3. lactation |
| Precautions | 1. Uric acid level monitoring recommended 2. Hepatic impairment |
| Adverse Effects | GIT disturbances |
| Pregnancy Category | D |
