| Category of Drug | Pralidoxime (2-PAM) is an Antidotes and Substances Used in Poisoning |
| Mechanism of Action | |
| Indications | Pralidoxime (2-PAM) is used for 1. Adjunct to atropine in the treatment of organophosphate poisoning and anticholinesterase overdosage used in the treatment of myasthenia gravis (mg) 2. Respiratory depression or severe muscle weakness due to carbamate poisoning |
| Well Known Pharmaceutical Brands | |
| Available dosage forms | INJECTION |
| Dose | |
| Contraindications | 1. Carbamate poisoning and organophosphates without anticholinesterase activity 2. Hypersensitivity to the drug |
| Precautions | 1. Impaired renal function 2. Large doses can cause neuromuscular blockade 3. Myasthenia gravis 4. Atropinizaon occur faster on concurrent use with atropine 5. Paediatrics 6. Allergies 7. Pregnancy |
| Adverse Effects | 1. Nausea 2. Vomiting 3. Blurred vision 4. Impaired accommodation 5. Headache 6. Dizziness 7. Hyperventilation 8. Muscular weakness 9. Transient elevation in SGOT/SGPT levels |
| Pregnancy Category | C |
