Category of Drug | Imipenem + Cilastatin is an Anti-Infective drug |
Mechanism of Action | |
Indications | Imipenem + Cilastatin is used for Severe aerobic and anaerobic Gram-positive and Gram-negative infections in hospital-acquired infections |
Well Known Pharmaceutical Brands | |
Available dosage forms | INJECTION |
Dose | |
Contraindications | 1. Hypersensitivity to beta-lactam antibiotics 2. Local anaesthetics of the amide-type and in patients with severe shock or heart block. |
Precautions | 1. Renal impairment 2. CNS disorders 3. Pregnancy 4. Lactations 5. Interactions |
Adverse Effects | 1. Nausea 2. Vomiting 3. Diarrhoea 4. Antibiotic-associated colitis 5. Taste disturbances 6. Tooth or tongue discolouration 7. Hearing loss 8. Blood disorders 9. Positive Coombs’ test 10. Allergic reactions 11. A slight increase in liver enzymes and bilirubin |
Pregnancy Category | C |