Category of Drug | Fosphenytoin is an Anticonvulsants/Antiepileptics drug |
Mechanism of Action | Fosphenytoin blocks frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials |
Indications | Generalized tonic-clonic status epilepticus. |
Well Known Pharmaceutical Brands | 1. FOSPHEN- INTAS PHARMA 2. FOSOLIN-ZYDUS CADILA 3. NEOFOST- NEON LABS |
Available dosage forms | INJECTION |
Dose | 10-20 mg PE/kg IV/IM |
Contraindications | Porphyria. |
Precautions | 1. Uremia 2. Hypoalbuminemia 3. Interactions 4. Pregnancy |
Adverse Effects | 1. Cardiovascular collapse and/or central nervous system depression 2. Nystagmus 3. Dizziness 4. Pruritus 5. Paresthesia 6. Headache 7. Somnolence 8. Ataxia 9. Hypotension. |
Pregnancy Category | D |
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