Fosphenytoin

Fosphenytoin- Drug Detail Profile

Category of DrugFosphenytoin is an Anticonvulsants/Antiepileptics drug
Mechanism of ActionFosphenytoin blocks frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials
Indications Generalized tonic-clonic status epilepticus.
Well Known
Pharmaceutical Brands
1. FOSPHEN- INTAS PHARMA
2. FOSOLIN-ZYDUS CADILA
3. NEOFOST- NEON LABS
Available dosage forms INJECTION
Dose 10-20 mg PE/kg IV/IM
Contraindications Porphyria.
Precautions 1. Uremia
2. Hypoalbuminemia
3. Interactions
4. Pregnancy
Adverse Effects 1. Cardiovascular collapse and/or central nervous system depression
2. Nystagmus
3. Dizziness
4. Pruritus
5. Paresthesia
6. Headache
7. Somnolence
8. Ataxia
9. Hypotension.
Pregnancy Category

References

  1. MOA
  2. Dosage: fosphenytoin

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