| Category of Drug | Doxycycline is an Anti-Infective drug Read More: Which are the popular antibiotics prescribed for infections? |
| Mechanism of Action | Tetracyclines such as doxycycline are thought to inhibit translation by binding to the 16S rRNA portion of the ribosome 1, preventing binding of tRNA to the RNA-30S bacterial ribosomal subunit, which is necessary for the delivery of amino acids for protein synthesis. As a result of the above actions, the initiation of protein synthesis by polyribosome formation is blocked. This stops the replication of bacteria and produces a bacteriostatic effect. |
| Indications | Doxycycline drug is used for 1. Respiratory-tract infections 2. urinary-tract infections 3. syphilis 4. lymphogranuloma venereum 5. pelvic inflammatory disease 6. Lyme disease 7. prophylaxis of malaria for pregnant women and non-immune individuals at risk |
| Well Known Pharmaceutical Brands | DOXICIP- CIPLA DOXIFIC- GUFIC DOXT-S- DRL DOXYFAV- AUREATE HEALTHCARE DOXYTOP- OVERSEAS DOXYTRAC- INVISION DOXYWELL- NOEL PHARMA |
| Available dosage forms | 1. TABLETS/CAPSULES 2. SYRUP  |
| Dose | Initial dose: 200 mg orally on the first day, given in 2 divided doses (100 mg every 12 hours) Maintenance dose: 100 mg orally once a day OR 50 mg orally every 12 hours |
| Contraindications | 1. Pregnancy 2. Children 3. Porphyria 4.Systemic lupus erythematosus 5. Hypersensitivity to tetracycline. |
| Precautions | 1. Avoid exposure to sunlight or sunlamps- photosensitivity reported 2. Renal impairment 3. Hepatic impairment 4. Lactation 5. Interactions |
| Adverse Effects | 1. Gastrointestinal disturbances 2. anorexia, erythema 3. Photosensitivity 4. Hypersensitivity reactions 5. Headache and visual disturbances 6. Hepatotoxicity 7. blood disorders 8. pancreas and antibiotic-associated colitis reported 9. Staining of growing teeth and occasional dental hypoplasia |
| Pregnancy Category | D |
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